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Therapy with GLP-1RA should therefore start with low doses that can be uptitrated ( GLP-1RA has been placed prominently in the international recommendations for the treatment of T2D as the first injectable agent before insulin due to the advantageous outcomes in cardiovascular safety studies that demonstrated a reduction of the combined cardiovascular endpoint three-component major adverse cardiovascular event (MACE-3

This aggressive titration schedule may contribute to the higher side effect rates seen in early treatment weeks

Diabetes Technol Therapeut

We have: good short- and medium-term data improving cardiovascular outcome data But we do not yet have decades of long-term weight-loss population data