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In April, the agency warned that some compounded semaglutide products contain salts and impurities, unlike the approved formulations, and may be less safe and effective

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In its phase 3 clinical trial published in The New England Journal of Medicine , 307 participants with overweight or obesity took a daily pill containing either 25 mg of semaglutide or a placebo

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While these pharmacovigilance findings underscore the need for heightened clinical vigilance, they represent associations rather than causal relationships, constrained by inherent limitations of FAERS such as reporting bias and confounding

A 2019 systematic review in Nutrients examined Clostridium butyricum supplementation across multiple studies, finding evidence for improved gut barrier function, reduced inflammation markers, and support for beneficial gut microbiota composition