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In addition, tirzepatide administration reduced the levels of YKL-40 and leptin versus placebo and dulaglutide treatment.37 Tirzepatide treatment at a dose of 15 mg also decreased ICAM-1 levels compared with placebo and dulaglutide administration and reduced high-sensitivity C-reactive protein levels compared with baseline and placebo treatment, but not dulaglutide treatment.37 The mechanism by which tirzepatide reduces these inflammatory markers is not fully understood

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