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Tuttle et al

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The results of the STEP-HFpEF trial showed that for obese patients with HFpEF, although treatment with Semaglutide led to a reduction in lean body mass, the 6-minute walk distance was significantly improved [58]

For those interested in this approach, formulations centered on Akkermansia and SCFA-supporting pathways are increasingly explored: Akkermansia muciniphila formulation Why this matters: GLP-1 drugs suppress appetite, but microbiome repair rebuilds the metabolic ecosystem that determines long-term results