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Mirroring data from sAC / mice, depletion of sAC in human caSMCs through a siRNA also abrogated cAMP responses to GLP-1(2836) (Figure 2I), providing further evidence of a nonreceptor, sAC-dependent mechanism

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3 GLP-1 Receptor Agonists (GLP-1RAs) in the Central Nervous System and the Energy Balance in Rodents GLP-1 is synthesized in NTS neurons that project to GLP-1R-expressing regions, such as the paraventricular nucleus (PVN) and ARC [23]

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