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Table 5 Results of a 26-week Open-label Trial of Liraglutide Injection Compared to Sitagliptin (both in combination with metformin) in Adults with Type 2 Diabetes Mellitus a Figure 4 Mean HbA 1c for Adult Patients with Type 2 Diabetes Mellitus who Completed the 26-week Trial and for the Last Observation Carried Forward (LOCF, intent-to-treat) data at Week 26 Combination Therapy with Metformin and Insulin This 26-week open-label trial enrolled 988 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA 1c 7-10%) on metformin (1,500 mg/day) alone or inadequate glycemic control (HbA 1c 7-8.5%) on metformin (1,500 mg/day) and a sulfonylurea

Understanding this distinction is important when considering reports of period changes in women taking GLP-1 medications

The ones cited in every press release announcing this drug as a breakthrough

We need 5-year and 10-year data to fully understand retatrutide's safety profile over the duration most patients will require

Retatrutide raises resting heart rate by about 5-10 bpm

The study concludes that greater focus on communication around OMM use and healthy changes in the family may provide increased positive effects to children, while supporting parents in long-term adherence to weight management interventions