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Table 1 summarizes the characteristics and main findings of the 11 included studies

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Semaglutide has received FDA approval for cardiovascular event risk reduction in 2020 and, most recently, kidney disease risk reduction in 2025 [14, 15, 3032]

Glucagon-like peptide-1 secretion from canine L-cells is increased by glucose-dependent insulinotropic peptide but unaffected by glucose

These combinations might indicate conditions requiring evaluation like gastritis, ulcers, or infection

Common Anticoagulants and GLP-1 Compatibility Warfarin (Coumadin) is compatible with semaglutide and tirzepatide, but requires the most intensive monitoring because its narrow therapeutic window means small dose changes create large clinical differences