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A Novo Nordisk spokesperson pointed out that NAION is not listed on approved labels as an adverse drug reaction for the marketed formulations of semaglutide. They also noted limitations in the Mass Eye and Ear study, such as its small and non-randomized sample group

Obesity has harmful effects on various body systems, most notably on the cardiovascular and endocrine systems, but also on the kidneys, liver, lungs, joints, and immune system [17]

Overall, they are considered well tolerated for most people

For researchers interested in the comparison between tirzepatide and next-generation compounds like retatrutide, which adds a third receptor (GCG), our guide to retatrutide versus semaglutide provides useful context, as does our three-way comparison of semaglutide, tirzepatide, and retatrutide

By the end of the study, most patients no longer met the criteria for type 2 diabetes based on that metric

Quantified by the restricted mean survival time (RMST) analysis, over the oneyear followup, the GLP1 RA group experienced 3.3 days fewer on average free from depression compared to the SGLT2i group (95% CI for the difference, 1.60 to 5.02 days