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Yes, chronic constipation can potentially lead to haemorrhoids, anal fissures, faecal impaction, or rectal prolapse, making it important to address symptoms promptly

Lancet 377:13411352 Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, Tam PY, Troupin B, Day WW (2012) Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)

The SP promotes protein secretion from cells, while the FCS is cleaved in the Golgi apparatus and on cell membrane, leading to the secretion of bioactive Exe4 (Fig
Taylor points out that the findings contradict earlier concerns about suicide

I., Knerr, L., Drury, W

Tirzepatide (Mounjaro, Zepbound) may be more effective than injectable semaglutide (Ozempic, Wegovy)
