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The graphical abstract of the manuscript has been presented in Figure 2

Studies consistently show that weight regain begins soon after stopping medication and is proportional to the amount of weight originally lost: Semaglutide (Wegovy) : In the STEP 1 extension study, participants who lost an average of 17% of their body weight regained approximately two-thirds of that weight within one year of stopping the medication

Among adults receiving 36 mg orforglipron, 50.1% lost at least 10% of their body weight at 72 weeks

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A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

For detailed comparison of these medication options, see our Zepbound vs Wegovy guide