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Leptin and obesity: role and clinical implication

Recently, several multi-targeting agonists of GIPR, GLP-1R, or GCGR for treating T2DM and obesity have been in clinical trials

Retatrutide, with triple-target effects (it works at the two receptors mentioned above and the glucagon receptor), caused people to lose about a quarter of their body weight after a year in a Phase II study (Jastreboff AM et al, N Engl J Med 2023;389(6):514526), although a follow-up study found the weight loss more in line with tirzepatide

Gala GLP-1 Tirzepatide and Semaglutide Searches: What Those Terms Mean and What to Confirm Before You Assume Searches for "Gala GLP-1 tirzepatide" and "Gala GLP-1 semaglutide" are among the most common queries tied to this platform

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Pathophysiology, diagnosis and management of postoperative dumping syndrome