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Doerr, S., Harvey, M

Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats

Interestingly, administration of liraglutide in mice with selective disruption of the cardiomyocyte GLP-1R ( Glp1r CM/ ) generated from MerCreMer transgenic mice expressing tamoxifen-inducible Cre driven by the -myosin heavy chain promoter, still produced robust cardioprotection and increased survival, suggesting that cardiomyocyte GLP-1R activation is not required for adaptive responses to ischemic and cardiomyopathic injury mediated by liraglutide (Ussher et al
Kranz, J.J

At the highest dose, people lost an average of 28% of their body weight when they took retatrutide and stayed on it as prescribed in the trial

Once weekly (OW) semaglutide is used as an example to illustrate how the authors might switch to a different GLP1RA in clinical practice
