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This is according to a national survey conducted by RAND, a nonprofit, nonpartisan research organization

Sequencing matters: many patients complete ultrasound therapy first, then add filler after 24 weeks or wait a similar interval after recent filler

This process, called central sensitization, involves neuroinflammation, specifically activation of microglial cells in the brain and spinal cord

El-Sahar AE, Safar MM, Zaki HF et al (2015) Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: implication of the oxidative-inflammatory-apoptotic pathway