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Drug exposure The study cohort consisted of new users of GLP-1RAs (dulaglutide, exenatide, liraglutide, lixisenatide or semaglutide), SGLT2 inhibitors (canagliflozin, dapagliflozin or empagliflozin), metformin and other second- or third-line glucose-lowering drugs (thiazolidinediones, dipeptidyl peptidase-4 inhibitors, sulfonylureas, meglitinides, -glucosidase inhibitors, insulin or a combination of glucose-lowering drugs)

treat the numbers as approximate, because methods and populations differ across studies

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The most commonly reported side effects of GLP-1 receptor agonists, documented across multiple large randomized controlled clinical trials enrolling thousands of participants, are gastrointestinal: nausea, vomiting, diarrhea, constipation, and abdominal discomfort, all of which are most commonly reported during the initial titration phase when dosage is being escalated from a low starting point toward a therapeutic target and the body is still adapting to the mechanism of action

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Most midlife patients find GLP-1 side effects minimal and manageable, especially when starting with lower doses that allow gradual adjustment