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Very low calorie diets periodically, meal replacement programs, or intermittent fasting approaches may help some individuals maintain weight loss after tirzepatide discontinuation

Part of what they look for is too-rapid weight loss which, in addition to straining vital body functions, can accelerate muscle loss

And Ive seen moments where youve also come on and said, Hey, Ive said this in the past

Why Tapering Matters Tapering allows the body time to: Recalibrate hunger and satiety signals Adjust energy expenditure gradually Rebuild metabolic flexibility Stabilize weight before full discontinuation A slower transition reduces the shock to the system and lowers rebound risk

At 68 weeks, treatment was stopped but a small group continued taking semaglutide for a year as part of an extension trial