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[Google Scholar] 31.Connor A, Donsmark M, Hartoft-Nielsen M-L, Sndergaard FL, Bkdal TA

The SURMOUNT-5 trial (published in the New England Journal of Medicine, 2024) changed that
A slope of 0.06 corresponds to an increase in exposure of 14% in subjects with a CL CR of 10 mL/min versus subjects with a CL CR of 90 mL/min
Without enough protein, weight loss happens but a significant portion of it will be muscle

Electrolyte imbalance is another major factor in muscle health