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To assess safety, we performed next-generation sequencing to evaluate the on-target site and the top 10 potential off-target sites in liver genomic DNA from in vivo knock-in mice

Some highly effective systemic anticancer drugs, such as paclitaxel and docetaxel, are substrates of the Pgp transporter

References Kankane VK, Warade AC, Misra BK (2019) Nonvestibular schwannoma tumors in the cerebellopontine angle: a single-surgeon experience

In rare cases, more severe side effects like chest pain and changes in heart rate may occur, necessitating immediate medical attention
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Medications have also been shipped or stored at improper temperatures, rendering the medication ineffective or, worse yet, potentially toxic
