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Common side effects include: Nausea Stomach discomfort Reduced appetite Diarrhea Constipation When used with other glucose-lowering medications, particularly insulin or sulfonylureas, there may be an increased risk of hypoglycemia (low blood sugar)

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Respective control mice (lean and ob/ob ) receive saline every 24 hours

Meta-analyses of berberine trials show modest reductions in hemoglobin A1c (approximately 0.5-0.7%) and fasting glucose, with variable effects on body weight, though many studies have methodological limitations and high heterogeneity