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Abstract Objective To synthesize the current preclinical and clinical evidence on the utility and potential mechanisms of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as a therapeutic strategy for major ophthalmic diseases, including diabetic retinopathy, glaucoma, and age-related macular degeneration

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Do not use if hypersensitive (allergic) to semaglutide or any of the excipients Do not use if there is a personal history of medullary thyroid carcinoma (MTC) Do not use if Multiple Endocrine Neoplasia type 2 (MEN2) is present Do not use during pregnancy, breastfeeding, or if planning to conceive Side effects of Wegovy Always read the package leaflet or SmPC for the complete and up-to-date list

Compounded semaglutide from PlexusDx starts at $149 per month through licensed 503A compounding pharmacies and is available across all 50 states without insurance

Trials were conducted in accordance with the Declaration of Helsinki and the Council for International Organizations of Medical Sciences International Ethical Guidelines, the International Conference on Harmonisation Good Clinical Practices Guideline, and other applicable laws and regulations