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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]

10-15 minutes after meals: This tends to reduce post-meal peaks and supercharge the circulating meal insulin, so less is required for the same effect

Reduces skin laxity

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Colorado Medicaid excludes them for weight loss
