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The LEADER trial 28 (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) studied a 1.8-mg dose in more than 9,000 patients with type 2 diabetes and found the incidence of acute pancreatitis was similar between the liraglutide and placebo groups (0.4% vs 0.5%, respectively)

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The poor adherence to long term treatment with AOMs evident in clinical practices, requires the design of effective algorithms based on the pathophysiology of obesity, to provide the most effective long-term strategies for sequential treatment with different AOMs and other modalities for body weight maintenance
