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doi:10.1523/JNEUROSCI.0175-20.2020

However, significant individual variation exists based on factors such as: Body composition and weight distribution volume may differ Metabolic rate affects how quickly proteins are broken down Dose and duration of treatment higher doses and longer treatment may extend elimination time Individual patient factors age, overall health status, and concurrent medications Patients who have been taking Wegovy at the full 2.4 mg maintenance dose should expect the medication to remain active in their system for several weeks after discontinuation

But it should be the last time the industry is caught planning for yesterdays demand

Research shows that weight loss plateaus around 16 to 20 weeks of therapy, after which continued use helps maintain the loss rather than produce rapid additional changes

No public efficacy readouts for either program as of April 2026

Research continues into additional potential benefits and applications