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Presentation 238-O presented at American Diabetes Association (ADA) 76th Scientific Sessions, New Orleans, LA, U.S., 2016

Acta Pharmaceutica Sinica B 4, 135-140
Participants, investigators and all trial personnel (except the independent data monitoring committee) are blinded to treatment assignment

Some common side effects of GLP-1 medications include decreased appetite, feeling nauseous, vomiting, diarrhea, lightheadedness, mildly elevated heart rate (tachycardia), risk of infections, headaches, and stomach discomfort or indigestion

Receptor pharmacology studies suggest that tirzepatide engages the hGIPR in a manner similar to GIP but displays biased signaling at the GLP-1R to favor cAMP generation over beta-arrestin recruitment (Figure 2) 4749