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No hormonal effects

This difference in immune activity between primary and metastatic tissues on the basis of GLP-1R expression could be indicative of GLP-1R-induced immunosuppressive activity in the tumor environment

Its likely that GLP-1 RAs (or their combinations) will be part of a future MASH therapy regimen, given weight loss is the cornerstone treatment and GLP-1 causes weight loss plus some direct hepatic fat reduction

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While epigenetic mechanisms such as histone modifications and DNA methylation have undoubtedly provided valuable insights into the regulation of gene expression in NDDs, it is essential to recognize that these processes alone do not fully explain the complexities of NDD pathophysiology
