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AT1R expression in mesangial cells and podocytes, induced by high glucose levels, promotes intracellular expression of profibrotic and pro-inflammatory mediators, such as transforming-growth factor beta (TGF- ), vascular endothelial growth factor (VGEF), and interleukin-6 (IL-6) leading to hyperplasia and hypertrophy, mainly of the proximal tubule, together with extracellular matrix production (34)

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Small intestinal stricture and volvulus-type intestinal obstruction are rare in adults

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These findings align with the literature suggesting that rapid weight loss may increase gallstone-related pancreatitis risk

Subsequently, we assessed the effectiveness of these three drugs in controlling blood glucose levels, reducing weight, and improving serum biochemical indicators and DKD