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Given the previously observed cardioprotective actions of GLP-1 in the absence of the GLP-1R, these data suggest that the ex vivo heart may not effectively metabolize GLP-1 to GLP-1(2836)

They reduce blood sugar, promote weight loss, and lower cardiovascular risk in appropriate patients

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Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjoth TV et al (2015) Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial

Meanwhile, Wegovy is facing tough competition from Eli Lilly's weight-loss therapy Zepbound (tirzepatide), which outperformed its rival in the head-to-head SURMOUNT-5 trial