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The medication slows gastric emptying, which can reduce intestinal motility and lead to difficulty with bowel movements within the first few weeks of therapy

Food and Drug Administration (FDA) nod as a weight-loss medication in June 2021 under the brand name Wegovy

Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis

This is not dangerous and typically resolves within minutes

Data availability Researchers can request access to data from the TriNetX research network through the TriNetX platform ( However, this may involve associated costs, require a data-sharing agreement, and no patient-identifiable information can be accessible

How Semaglutide and Testosterone Work on Different Body Systems Semaglutide acts primarily on appetite-regulating hormones in the brain and gut, signaling satiety earlier during meals and reducing cravings between eating occasions