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Subsequent studies have shown that in the majority of cases of APCr, it arises from a GA missense mutation at nucleotide 1691 in the F5 gene leading to an Arg506Gln mutation in which the Arginine residue at position 506 in Factor Va is replaced by a Glutamine and this abolishes an inactivation cleavage site for Activated Protein C [APC]

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Another popular name for this condition is impaired fasting glucose

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