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Phenytoin Clinical trial data suggested that sertraline hydrochloride may increase phenytoin concentrations [See Drug Interactions (7.1)]

The trial was double-blinded, meaning neither the investigators nor the persons with Parkinsons were made aware of who was actually receiving an active drug (rather than a placebo/inactive drug)

Patients who require higher doses for optimal control will naturally take longer to experience maximum benefits

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Methotrexate, by contrast, suppresses immune cell proliferation and reduces inflammatory moleculesa mechanism used for rheumatoid arthritis, lupus, and other autoimmune conditions