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Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)

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Then, the FDA declared in late 2024 that tirzepatide was no longer in shortage, and it determined that semaglutide was no longer in shortage in early 2025