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Am J Physiol - Endocrinol Metab (2019) 316(4):E56877

Rationale for Combination Therapy SGLT-2 inhibitors induce natriuresis and osmotic diuresis which in turn decrease cardiac preload and afterload, alleviate increased intraglomerular pressure and exert a downstream effect on blood pressure

disminuye la produccin de glucagn (una hormona que eleva la glucemia)

GLP-1 receptor agonists mimic the gut hormone GLP-1 to stimulate insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite
