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doi: 10.7570/jomes22067

Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach

That was Finley's situation

P., and Parmar G., Teneligliptin in Management of Type 2 Diabetes Mellitus, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 9 (2016): 251260, 10.2147/DMSO.S106133

The success of exenatide helped launch a wave of newer drugs built on the same basic idea

The vascular protective effects of liraglutide were associated with improved plaque stability (14), attenuated endothelial cell dysfunction (14, 15), reduced ICAM-1 expression in the aortic endothelium (12, 15), decreased leukocyte rolling on the endothelium and infiltration of myeloid cells into the vascular wall (13, 16), suppressed foam cell formation (13), and inhibition of vascular smooth muscle cell proliferation (10)
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