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Healthcare providers may avoid prescribing topiramate for individuals with: A history of suicidal thoughts or behaviors A history of kidney stones Metabolic acidosis Bone conditions like osteopenia, osteomalacia, or osteoporosis Glaucoma Respiratory issues like asthma or COPD Depression or mood disorders Growth problems Thyroid disease Liver disease Kidney diseases Topiramate can increase the risk of kidney stones, so it's essential to stay well-hydrated while taking the medication

00:08:09 Vickie Danaher It must be swallowed whole with a sip or no more than 4 ounces of water

Do not stop abruptly without medical guidance

It is a full agonist at hGLP-1R but displayed poor potency (0.7 M) that is more than 1000-fold lower than GLP-1 itself

doi:10.3390/medicina59050985 Chandrakumar H, Khatun N, Gupta T, GrahamHill S, Zhyvotovska A, McFarlane SI

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