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Kiyosue, S

Conclusions The present study elucidates novel mechanistic and transcriptomic pathways enabling the weight-reducing effects of liraglutide treatment in obese mice

Within the GLP-1RA group, discontinuing treatment for even 0.5 years was associated with a higher MACE risk compared to continued use

In this article, well explore how retatrutide and related GLP-1 medications affect lipids, with a special focus on the glucagon receptor pathway that may explain their LDL-lowering effect

Given the heterogeneity among GLP-1RAs in terms of pharmacokinetic profiles, therapeutic efficacy, adverse event rates, and dosing regimens, each agent should be assessed individually

Compared to peptide GLP- 1 receptor agonists, orforglipron, exhibits less receptor desensitization by increasing cyclic AMP signaling [105]