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Id also raise the question of whether the incretins and other GLP-1 agonists will ever be free of adverse GI symptoms, as it seems intrinsic to the drugs mechanism.

Methods We conducted a population-based propensity-matched retrospective cohort study using TriNetX
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Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials

Five scientists won this years Breakthrough Prize in Life Sciences for their work on GLP-1 and the development of drugs for diabetes and obesity.
