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Some individuals carry genetic variants that reduce GLP-1 receptor expression, meaning standard semaglutide doses may produce weaker appetite suppression

In murine and human islets, GLP-1, via phospholipase C (PLC), leads to an activation of PKC, followed by membrane depolarization and stimulation of insulin secretion

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This worry comes from research published in the Endocrine Journal with other drugs in the same group, like semaglutide, that showed there could be an increased risk of things like deep vein thrombosis (DVT) and problems like that

Our findings suggest that GLP-1 medications could potentially have a dual benefit for patients, not only in managing their diabetes or obesity but also in potentially reducing the likelihood of depression and anxiety diagnoses, Kersten Bartelt, RN, a clinician at Epic Research, told Healio

Medications known to cause night sweats include antidepressants (SSRIs, SNRIs, TCAs), opioids, hypoglycemic agents, corticosteroids, thyroid hormone, tamoxifen, and niacin