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15 An in vitro decidualization model, in which the endometrial stromal cells were exposed to cAMP and progesterone for 4 to 14 days, has been successfully used to advance the understanding of endometrial factors associated with PCOS, particularly by identifying abnormalities in the decidualization process of endometrial stromal cells 19 and noting the decreased expression of stanniocalcin1, 20 a marker of endometrial receptivity

* Correspondence: Ming-Hsien Tsai, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The 15 nmol/kg dose modestly reduced glucose and HbA1c but failed to induce normoglycemia (defined as blood glucose 10%)

The latter, she says, will have had praise for their weight loss

Common adverse effects reported with Ozempic include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, and abdominal pain (particularly during dose escalation) Injection site reactions : redness, itching, or discomfort at the injection site Hypoglycaemia : especially when used in combination with insulin or sulfonylureas (doses of these medications may need reduction to minimise this risk) [3] [14] More serious but less common risks include: Pancreatitis : patients should be advised to seek immediate medical attention if they experience severe, persistent abdominal pain [22] [23] Gallbladder disease : including cholelithiasis and cholecystitis Diabetic retinopathy complications : particularly in patients with pre-existing retinopathy Acute kidney injury : risk increases with dehydration from severe gastrointestinal side effects Thyroid C-cell tumours : observed in rodent studies, though the relevance to humans remains uncertain [3] [14] Ozempic should not be used during pregnancy and should be discontinued if pregnancy occurs

Age is not a barrieradults of any age who meet health criteria may qualify, though dosing and monitoring may be individualized for patients over 65 or with specific comorbidities