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Mesolimbic reward areas receive direct innervation from GLP-1-producing neurons, indicating hindbrain-derived GLP-1 may influence reward-related behaviors ( In terms of clinical evidence, randomized clinical trials have shown that the GLP-1 receptor agonist exenatide may reduce alcohol consumption, particularly in individuals with co-occurring alcohol use disorder and obesity (ClinicalTrials.gov) or recently completed ( Given the lack of evidence supporting a potential effect of GLP-1 receptor agonists as treatment in methamphetamine (METH) dependence in either a clinical or preclinical setting, the aim of this study was to investigate whether administration of liraglutide could reduce METH intake in a rat model of intravenous self-administration (IVSA)

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BRET assays and in vitro quantification of PPAR-responsive genes were performed as described in Supplementary Information 1