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In vitro, in differentiated human DA neurons, IR was associated with increased -synuclein and ROS levels, as well as mitochondrial depolarization, which may be mediated by polo-like kinase-2.177 In vivo, mitochondrial dynamics-related factor Parkin was significantly reduced in the substantia nigra of a mice fed a high-fat diet and a diabetic mice, leading to the accumulation of Parkin-interacting substrate and the reduction of PGC-1.41 Also, high glucose levels may modulate Parkin/PINK1-mediated mitochondrial autophagy in DA cells through the thioredoxin-interacting protein.178 All the above mechanisms suggest that diabetes-related metabolic factors may promote PD by regulating the mitochondria
23 As shown in TABLE 2 , recommended nonpharmacologic interventions to reduce GI AEs include dietary modifications such as eating smaller, more frequent meals
Most side effects resolve as your body adjusts or improve with dose modifications
PMID: 26 LiTFuJZengZCohenDLiJChenQet al
For FDA-approved uses, semaglutide is meant to be taken in specific, clinically tested, weekly dosages, not in daily micro-doses
A total of 858 annotated and 210 unannotated plasma metabolites were measured
