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Diabetes Complications 28 , 399405 (2014)

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The FDA approves at 27 with comorbidities

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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Nexe-Larsen C.C., Srensen P.H., Hausner H., Agersnap M., Baekdal M., Brnden A., Gustafsson L.N., Sonne D.P., Vedtofte L., Vilsbll T., et al

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Note: This is intended as a guide only

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The three hormone receptors targeted by retatrutideGLP-1, GIP, and glucagonrepresent the holy trinity of metabolic regulation, each controlling different but interconnected aspects of energy homeostasis [2]

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Increased heart rate (+4-7 bpm) observed at higher doses, attributable to glucagon receptor component

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