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Body composition data from the SURMOUNT-1 trial of tirzepatide show that approximately 75% of the weight lost was fat mass and 25% was lean mass 2

Reich, N

Dalton M, Buckland N, Blundell J

Tapering versus abrupt cessation The clinical trials did not specifically study tapering protocols, but physiological principles suggest a gradual dose reduction may produce a smoother transition than abrupt cessation

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