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Clinical trial data shows that only 3-5% of participants report any injection site issues, and the vast majority describe these as mild and transient

Wang R, Liu X, Hentges ST, Dunn-Meynell AA, Levin BE, Wang W, et al

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Efficacy and Safety of a Fixed-Ratio Combination of Insulin Degludec and Liraglutide (IDegLira) Compared With its Components Given Alone: Results of a Phase 3, Open-Label, Randomised, 26-Week, Treat-to-Target Trial in Insulin-Naive Patients With Type 2 Diabetes

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D12492i) for 20 weeks before ICV cannulation surgery and were 6 months old at the start of the study