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Grip strength declining 38 kg from baseline often months before any change appears on a body composition scan

In Table 1, all the principal trials investigating the CV outcomes upon GLP-1RA administration are listed

The hormone then performs several important functions: stimulates insulin release from the pancreas reduces glucagon (which raises blood sugar) slows stomach emptying signals fullness to the brain helps stabilise blood-glucose levels after meals In simple terms, GLP-1 acts as a metabolic traffic controller , helping the body process food efficiently and preventing large spikes in blood sugar

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GLP-1 receptor agonists enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways