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While the close relation between GLP-1 and insulin signalling is undoubtedly important in cognition, it is crucial to highlight that beyond this mechanism, GLP-1R mimetics upregulated several neuroprotective growth factors such as: insulin-like growth factor 1 (IGF-1) (165), brain-derived neurotrophic factor (BDNF) (166), glia-derived neurotrophic factor (GDNF) (164), as well as vascular endothelial growth factor (VEGF) (157, 158)

In the therapeutic landscape of pediatric obesity, GLP-1R agonists have emerged as particularly effective agents when compared with other available strategies

The flat monthly pricing modelwhere dose escalations don't trigger cost increasesremoves the financial penalty for titrating toward your optimal therapeutic level, encouraging the dose adjustments that drive real-world success