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At the 10 mg/kg dose of GSBR-1290, the average food intake from day one to day six was only 59% of that in the Liraglutide group

For all these effects, different benefits have been attributed to DPP-4is (including improvement of oxidative stress, inflammation, fibrosis and apoptosis, endothelial function, and tissue reparation), related to renal protection and a variety of cardiovascular and metabolic clinical conditions beyond T2D, including hypertension, calcified aortic valve disease, atherosclerosis, and heart failure (HF) [47,68]
