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In an 18-month clinical trial of the experimental GLP-1 pill orforglipron, about 60 percent of people lost at least 10 percent of their body weight.

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Here we investigated the effects of the GLP-1 agonist exenatide on palatability-driven feeding regulation in adult male rhesus macaques (n=5) using a novel operant food intake paradigm with four meal schedule conditions where two types of pellets with different palatability values were offered as meal in all combinations in two consecutive daily feeding sessions (S1 and S2)

Growing evidence suggests that GLP-1 receptor agonists like semaglutide may offer unexpected benefits beyond weight loss, including potential migraine relief through metabolic and inflammatory pathways

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