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However, when cortisol resistance occurs, it leads to chronic low-grade inflammation, which is prevalent in about 27% of people with depression [76]

Chronic stress elevates cortisol levels, which can slow digestive motility, alter gut microbiome composition, and increase intestinal permeability

~ AlphaMD Most men don't realize that the gradual erosion of sleep quality, recovery, and body composition that comes with aging isn't simply "getting older" - it's largely the story of a declining growth hormone axis

Diabetes Study 74

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