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They share structural similarities with endogenous hormones and signaling molecules, which may partially explain why severe allergic reactions remain relatively uncommon compared to some other drug classes

JCI Insight 5 , e133429 (2020)

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Injection site reactions: Mild redness or itching at injection sites is common but should resolve quickly

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Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial