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The randomized, double-blind, placebo-controlled study tested various doses of Danuglipron against a placebo over 16 weeks

Previous WHO recommendations focused on the latter

74104), following standard protocols 65

Particularly, these models were characterized by increased fasting and post prandial LPS concentration, probably related to gut permeability alteration, which determined the increase of pro-inflammatory cytokines, like interleukin (IL-1) after the infusion [57]

Since both diabetes and obesity are risk factors for PDAC, there is a potential role for the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) for PDAC risk reduction

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