side effects of glp 1 agonists Gastrointestinal (GI) GLP-1 Receptor —Semaglutide —Liraglutide —Dulaglutide Comparison of adverse effects between

In rodent models, a number of studies have found that GLP-/GIP dual agonists group mice have reduced fat mass, decreased circulating cholesterol, and lost weight, which has excellent weight loss effect

They related several stories

A randomized double-blind trial found GLP-1 increased significantly in participants taking green tea extract versus placebo

doi: 10.1016/S0140-6736(23)01291-6 82 AmberyPParkerVEStumvollMPoschMGHeiseTPlum-MoerschelLet al

Unlike existing peptide predecessors that are digested by stomach acid unless armored with absorption enhancers, orforglipron is a chemicala small molecule designed to survive the GI tract and activate the GLP-1 receptor directly

Conarello and colleagues found less weight-gain independent of the diet, and marked hypertrophy in the HFD-fed KO mice in epididymal white (eWAT) and brown adipose tissue (BAT)